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Genetic variations of Wnt/β-catenin signaling pathway microRNA regulators as novel prenatal biomarkers of fetal growth restriction syndromeстатья
- Авторы: Dema Alset, Butenko Elena V., Pokudina Inna O., Shkurat Tatiana P., Kuznetsova Natalia, Bushtyreva I.O.
- Журнал: Gene Reports
- Том: 35
- Год издания: 2024
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- DOI: 10.1016/j.genrep.2024.101914
- Аннотация: Fetal Growth Restriction (FGR) remains the second cause of perinatal mortality with inconsistent results in term of etiology and diagnosis. Wnt/β-catenin signaling pathway is essential in FGR pathophysiology. We aimed to study the associations of genetic variants in regulatory microRNAs of Wnt/β-catenin with FGR risk. The study included 65 pregnant women classified into FGR and control group. Leukocytes genomic DNA was extracted and genotyped with allele specific PCR using the designed primers for the following variations: miR-125a rs12976445, miR-365b rs121224, miR-33a rs9620000, miR-149 rs2292832 and WNT3a rs752107. χ2-test was used to evaluate the association with FGR and SNP-SNP interaction was assessed in MDR. According to our data, Mutant allele (C) of miR-33a rs9620000 was shown as associated with FGR (OR = 2.5; CI 95 % 1.1–8.79; p = 0.031). In addition, WNT3a rs752107 mutant allele (G) can be suggested as FGR risk factor (OR = 2.68; CI 95 % 1.16–6.2; p = 0.009). MDR analysis figured that women with miR-125a (TT)* miR-149 (AA) have significantly higher risk of FGR. We suggest maternal miR-33a rs9620000 and WNT3a rs752107 as candidate prenatal risk factors of FGR syndrome. This supports the efforts of finding new non-invasive biomarkers of FGR as one of the main challenges in genecology. Our findings will improve prognosis, diagnosis and interventions in FGR cases where doctors can use genetic screening results to make the suitable decision of using fetal growth supporting medicines.
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