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The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65 years Review Article , 2017, v.71, Part B, P:130-141статья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 января 2018 г.
- Авторы: Poletaeva I.I., Surina N.M., Kostina Z.A., Perepelkina O.V., Fedotova I.B.
- Журнал: Epilepsy and Behavior
- Том: 71
- Номер: Part B
- Год издания: 2017
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 130
- Последняя страница: 141
- Аннотация: The more recent history and main experimental data for Krushinsky–Molodkina (KM) audiogenic rat strain are 18 presented. The strain selection started in late 1940. Nowthis strain is inbred, and two newstrains aremaintained 19 in a laboratory in parallel. These strains originated fromKM ×Wistar hybrids andwere bred (starting from2000) Q2013 for no-seizure and intense audiogenic seizure phenotypes, respectively. The experimental evidences of audiogen- 21 ic seizure physiology were accumulated in parallel (and usually ahead) with data on other audiogenic-prone 22 strains. The peculiar feature,whichwas investigated in the KMstrain, is their vulnerability to brain hemorrhages. 23 Thus, the KM strain is used not only as the genetic model of seizure states, but also as the model of brain blood 24 flow disturbances.
- Добавил в систему: Полетаева Инга Игоревна