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Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticlesстатья
- Авторы: Filimonova M.V., Kolmanovich D.D., Tikhonowski G.V., Petrunya D.S., Kotelnikova P.A., Shitova A.A., Soldatova O.V., Filimonov A.S., Rybachuk V.A., Kosachenko A.O., Nikolaev K.A., Demyashkin G.A., Popov A.A., Savinov M.S., Popov A.L., Zelepukin I.V., Lipengolts A.A., Shpakova K.E., Kabashin A.V., Koryakin S.N., Deyev S.M., Zavestovskaya I.N.
- Журнал: Doklady Biochemistry and Biophysics
- Том: 516
- Номер: 1
- Год издания: 2024
- Издательство: M A I K Nauka - Interperiodica
- Местоположение издательства: Russian Federation
- Первая страница: 111
- Последняя страница: 114
- DOI: 10.1134/s1607672924700819
- Аннотация: Abstract—Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates thepossibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumorcells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete deathof EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80%tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing theproton irradiation effect on tumor cells and requires further research to increase the therapeutic index of theapproach.Keywords: proton therapy, radiosensitizers, nanoparticles, gold, tumor therapy
- Добавил в систему: Шпакова Кристина Евгеньевна