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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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An Integrative Approach to the Study of Cognitive Abilities in a Non-Human Primate Model in a Virology Laboratory Environmentстатья
- Авторы: Rogova A., Kalyanova A., Rogova Y., Fedina M., Siniugina A., Ishmukhametov A., Karganova G.
- Журнал: BRAIN SCIENCES
- Том: 26
- Номер: 14
- Год издания: 2024
- DOI: 10.3390/brainsci14070635
- Аннотация: Non-human primates, due to their similarities in immune response to humans, are the preferredmodel for studying infectious processes and any associated cognitive impairments. Behavioraltests are indispensable for investigating pathogenesis in neuroinfections, especially those that donot manifest with noticeable clinical symptoms, as well as in the transition to a chronic form of thedisease. Modeling viral infection requires specialized experimental conditions. Our work describestechniques for investigating mnemonic functions, tiredness, attentional focus, quick-wittedness, andbasic behavioral responses in primates under the assumed conditions for infections with virusesthat do not have an airborne route of transmission. It also outlines approaches to the training andselection of primates for virological research, as well as analyzing gender differences in learningabilities, the impact of housing conditions on the results, and the correlation between training successand behavioral test scores. These methods will allow a more detailed study of non-human primatesas a model for researching cognitive and behavioral impairments under infectious and immune stress,as well as the design of less energy-intensive experiments for evaluating the efficacy and safety oftherapeutic and prophylactic strategies at early stages of infection.
- Добавил в систему: Карганова Галина Григорьевна