Synthesis, Photophysical Properties and Cytotoxic Activities of Isoxazole‐Containing Difluoroboron Complexes

Авторы: Sadovnikov Kirill S., Vasilenko Dmitry A., Astakhova Nadezhda E., Sazonov Artem S., Yakushev Alexei A., Gracheva Yulia A., Grishin Yuri K., Tafeenko Victor A., Milaeva Elena R., Averina Elena B.
Журнал: Journal of Heterocyclic Chemistry
Том: 61
Номер: 10
Год издания: 2024
Издательство: John Wiley & Sons
Местоположение издательства: Hoboken, NJ, United States
Первая страница: 1627
Последняя страница: 1636
DOI: 10.1002/jhet.4894
Аннотация: A large series of previously unknown isoxazole containing difluoroboron β-diketonate has been designed and synthesized from the available starting compounds. The photophysical properties of obtained compounds were studied, and the effects of the substituents in aromatic and isoxazole cycles of the BF2 complexes on the fluorescence were investigated. The effect of solvatochromism were demonstrated. Cytotoxic activity against MCF-7 (breast carcinoma), HCT-116 (colon carcinoma), A549 (pulmonary carcinoma) and WI38 (fibroblasts from lung tissue) cell lines was tested and moderate toxicity in the concentration range of 10–100 μM was found for several compounds.
Добавил в систему: Астахова Надежда Евгеньевна

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