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The Impact of 5-Substituted Uracil Derivatives on Immortalized Embryo Lung Cellsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 октября 2024 г.
- Авторы: Kabal'nova Natalia N., Grabovskiy Stanislav A., Andriayshina Nadezhda M., Egorov Vladislav I., Valiullin Lenar R., Nabatov Alexey A., Raginov Ivan S., Murinov Yurii I.
- Журнал: Letters in Drug Design and Discovery
- Том: 14
- Номер: 12
- Год издания: 2017
- Издательство: Bentham Science Publishers
- Местоположение издательства: Netherlands
- Первая страница: 1409
- Последняя страница: 1414
- DOI: 10.2174/1570180814666170502171640
- Аннотация: Background: Pyrimidine-based drugs stimulate tissue regeneration and immunity, two components that need to be improved in a number of respiratory diseases of different etiology (e.g. influenza and asthma). In the present study we investigated relationships between the character of substitutions in the uracil structure and the impact of the respective uracil derivatives on the immortalized lung cells. Methods: The level of cell proliferation, maximum tolerated dose and toxic effect of 5-substituted uracil derivatives (12 compounds) were studied on the immortalized lung epithelial cells and compared with the ones of 6-methyluracil. Results: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil had the lowest cytotoxicity among the studied compounds. Their maximal tolerated dosage values were 5 times higher whereas the proliferation index was increased by 25% and 75%, respectively, compared to 6-methyluracil, known for its positive effects on cell regeneration. Conclusion: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil have the best perspectives for further studies on their biological effects.
- Добавил в систему: Грабовский Станислав Анатольевич