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Signaling controversy and future therapeutical perspectives of targeting sphingolipid network in cancer immune editing and resistance to tumor necrosis factor-α immunotherapyстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 сентября 2024 г.
- Авторы: Sukocheva Olga A., Neganova Margarita E., Aleksandrova Yulia, Burcher Jack T., Chugunova Elena, Fan Ruitai, Tse Edmund, Sethi Gautam, Bishayee Anupam, Liu Junqi
- Журнал: Cell Communication and Signaling
- Том: 22
- Номер: 1
- Год издания: 2024
- Издательство: BioMed Central
- Местоположение издательства: London
- Номер статьи: 251
- DOI: 10.1186/s12964-024-01626-6
- Аннотация: Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the disruption of intracellular respiration and the development of various diseases, including cancer. Notably, copper-induced cell death was defined as cuproptosis which was also observed in malignant cells, representing an attractive anticancer instrument. Excess of intracellular copper leads to the aggregation of lipoylation proteins and toxic stress, ultimately resulting in the activation of cell death. Differential expression of cuproptosis-related genes was detectedin normal and malignant tissues. Cuproptosis-related genes were also linked to the regulation of oxidative stress, immune cell responses, and composition of tumor microenvironment. Activation of cuproptosis was associated with increased expression of redox-metabolism-regulating genes, such as ferredoxin 1 (FDX1), lipoic acid synthetase (LIAS), lipoyltransferase 1 (LIPT1), dihydrolipoamide dehydrogenase (DLD), drolipoamide S-acetyltransferase (DLAT), pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1), and pyruvate dehydrogenase E1 subunit beta (PDHB)).Accordingly, copper-activated network was suggested as an attractive target in cancer therapy. Mechanisms of cuproptosis and regulation of cuproptosis-related genes in different cancers and tumor microenvironment are discussed in this study. The analysis of current findings indicates that therapeutic regulation of copper signaling, and activation of cuproptosis-related targets may provide an effective tool for the improvement of immunotherapy regimens.
- Добавил в систему: Неганова Маргарита Евгеньевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | текст статьи | s12964-024-01743-2.pdf | 2,1 МБ | 10 сентября 2024 [Neganova83] |
| 2. | Экспертное_заключение_.pdf | Экспертное_заключение_.pdf | 564,6 КБ | 13 сентября 2024 [AleksandrovaYuR] |