Biological Activity of Hybrid Vaterite-Pectin Microparticles Towards Bacteria E. coli and Human Neutrophils

Авторы: Galyamina MA, Pobeguts OV, Firova RK, Mosievich DV, Kharaeva ZF, Panasenko OM, Balabushevich NG, Mikhalchik EV
Журнал: Bulletin of Experimental Biology and Medicine
Том: 177
Номер: 2
Год издания: 2024
Издательство: Springer Nature
Местоположение издательства: Switzerland
Первая страница: 238
Последняя страница: 242
DOI: 10.1007/s10517-024-06164-2
Аннотация: Interaction of microbiota with hybrid vaterite-pectin microparticles as an attractive multifunctional vehicle for mucosal delivery should not provoke infammation. Our purpose was to study the reaction of bacteria E. coli strain Mg1655 and isolate SharL from a patient with Crohn disease on the cultivation with hybrid microparticles and vaterite, and the subsequent activation of neutrophils. Vaterite-pectin microparticles enhanced leakage of ATP from bacteria. For E. coli Mg1655, the concentration of DNA decreased, while intracellular ATP increased. For E. coli SharL, the intracellular ATP decreased with simultaneous growth of DNA. Bacteria and microparticles together did not enhance activation of neutrophils in comparison with the particles per se in the medium without serum and in comparison with bacteria in the medium supplemented with serum; microparticles did not reduce functional activity of neutrophils.
Добавил в систему: Балабушевич Надежда Георгиевна

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