Asparagine level in hippocampus and working memory test performanceстатьяТезисы
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.
Аннотация:Previous studies show that asparagine level in the hippocampus might correspond to memory functioning. For example, decreased hippocampal asparagine level results in spatial memory deficits in mice (Kwon, 2000). Asparagine also affects normal long-term potentiation in rat hippocampus (Kapai, 2004). In the present study we compared asparagine levels in both hippocampi with working memory test performance in healthy humans.
Participants in the study were 8 right-handed females (mean age 59 ± 16) without neurological and mental disorders. All subjects performed verbal and spatial N-back (1- & 2-back) working memory tests. Asparagine levels (2.96 ppm) in both hippocampi were measured in vivo with 1H-NMR spectroscopy (3T MRI). As a control measurement we used asparagine levels in inferior parietal cortex (IPC). The data were analyzed by calculating non-parametric correlations (Spearman, p < 0.05) between individual behavioral and biochemical measurements. There were significant correlations between asparagine levels in the right hippocampus and verbal N-back task performance (r = 0.91, p < 0.003 for 1-back and r = 0.79 for 2-back tasks). Asparagine levels in the left hippocampus correlated negatively (−0.68) with spatial 1-back performance. No significant correlations between asparagine levels in IPC and memory test performance were revealed. Thus, relatively high asparagine levels in the right hippocampus is related to verbal memory capacity, whereas low levels in the left hippocampus correlate with spatial memory test performance.
This study was partially funded by Russian Humanitarian Science Foundation (RHSF) project # 13-06-00570.