Efficient methods for the synthesis of thieno[3,2-b]thiophene and thieno[3,2-b]furan derivativesстатья
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Дата последнего поиска статьи во внешних источниках: 2 сентября 2014 г.
Аннотация:A novel approach to the synthesis of thieno[3,2-b]thiophenes and thieno[3,2-b]furans bearing various substituents from readily accessible starting materials has been developed. The methodology is based on C- and O-alkylation of ethyl 4-hydroxy-2-methylthiophene-3-carboxylate with α-halo ketones, followed by cyclization.