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Beyond the Excluded Volume Effects: Mechanistic Complexity of the Crowded Milieuстатья
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 августа 2017 г.
- Авторы: Kuznetsova Irina, Zaslavsky Boris, Breydo Leonid, Turoverov Konstantin, Uversky Vladimir
- Журнал: Molecules
- Том: 20
- Номер: 1
- Год издания: 2015
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1377
- Последняя страница: 1409
- DOI: 10.3390/molecules20011377
- Аннотация: Macromolecular crowding is known to affect protein folding, binding of small molecules, interaction with nucleic acids, enzymatic activity, protein-protein interactions, and protein aggregation. Although for a long time it was believed that the major mechanism of the action of crowded environments on structure, folding, thermodynamics, and function of a protein can be described in terms of the excluded volume effects, it is getting clear now that other factors originating from the presence of high concentrations of "inert" macromolecules in crowded solution should definitely be taken into account to draw a more complete picture of a protein in a crowded milieu. This review shows that in addition to the excluded volume effects important players of the crowded environments are viscosity, perturbed diffusion, direct physical interactions between the crowding agents and proteins, soft interactions, and, most importantly, the effects of crowders on solvent properties.
- Добавил в систему: Туроверов Константин Константинович