Hydroxyapatite‐loaded macroporous calcium alginate hydrogels: Preparation, characterization, and in vitro evaluation

Drozdova, M.; Makhonina, A.; Gladkikh, D.; Artyukhov, A.; Bryukhanov, L.; Mezhuev, Y.; Lozinsky, V.; Markvicheva, E.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 июля 2024 г.

Авторы: Drozdova Maria, Makhonina Alika, Gladkikh Daria, Artyukhov Alexander, Bryukhanov Leonid, Mezhuev Yaroslav, Lozinsky Vladimir, Markvicheva Elena
Журнал: Biopolymers
Том: 115
Номер: 4
Год издания: 2024
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Первая страница: e23583
DOI: 10.1002/bip.23583
Аннотация: Hydrogels from natural polysaccharides are of great interest for tissue engineering.This study aims (1) to prepare hydroxyapatite-loaded macroporous calcium alginatehydrogels by novel one-step technique using internal gelation in water-frozen solu-tions; (2) to evaluate their physicochemical properties; (3) to estimate their ability tosupport cell growth and proliferation in vitro. The structure of the hydrogel samplesin a swollen state was studied by confocal laser scanning microscopy and was shownto represent a system of interconnected macropores with sizes of tens micron. Theswelling behavior of the hydrogels, their mechanical properties (Young's moduli) infunction of a hydroxyapatite content (5–30 mass%) were studied. All hydrogel sam-ples loaded with hydroxyapatite were found to support growth and proliferation ofmouse fibroblasts (L929) at long-term cultivation for 7 days. The obtained macropor-ous composite Ca-Alg-HA hydrogels could be promising for tissue engineering.
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Hydroxyapatite‐loaded macroporous calcium alginate hydrogels: Preparation, characterization, and in vitro evaluationстатья

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