International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Chen, X.; Tsvetkov, A.S.; Shen, H.; Isidoro, C.; Ktistakis, N.T.; Linkermann, A.; Koopman Werner, J.H.; Simon, H.; Galluzzi, L.; Luo, S.; Xu, D.; Gu, W.; Peulen, O.; Cai, Q.; Rubinsztein, D.C.; Chi, J.; Zhang, D.D.; Li Changfeng; Toyokuni, S.; Liu, J.; Roh, J.; Dai, E.; Juhasz, G.; Liu, W.; Zhang, J.; Yang, M.; Liu, J.; Zhu, L.; Zou, W.; Piacentini, M.; Ding, W.; Yue, Z.; Xie, Y.; Petersen, M.; Gewirtz, D.A.; Mandell, M.A.; Chu, C.T.; Sinha, D.; Eftekharpour, E.; Zhivotovsky, B.; Besteiro, S.; Gabrilovich, D.I.; Kim, D.; Kagan, V.E.; Bayir, H.; Chen, G.; Ayton, S.; Lünemann, J.D.; Komatsu, M.; Krautwald, S.; Loos, B.; Baehrecke, E.H.; Wang, J.; Lane, J.D.; Sadoshima, J.; Yang, W.S.; Gao, M.; Münz, C.; Thumm, M.; Kampmann, M.; Yu, D.; Lipinski, M.M.; Jones, J.W.; Jiang, X.; Zeh, H.J.; Kang, R.; Klionsky, D.J.; Kroemer, G.; Tang, D.

Авторы: Chen Xin, Tsvetkov Andrey S., Shen Han-Ming, Isidoro Ciro, Ktistakis Nicholas T., Linkermann Andreas, Koopman Werner J.H., Simon Hans-Uwe, Galluzzi Lorenzo, Luo Shouqing, Xu Daqian, Gu Wei, Peulen Olivier, Cai Qian, Rubinsztein David C., Chi Jen-Tsan, Zhang Donna D., Li Changfeng, Toyokuni Shinya, Liu Jinbao, Roh Jong-Lyel, Dai Enyong, Juhasz Gabor, Liu Wei, Zhang Jianhua, Yang Minghua, Liu Jiao, Zhu Ling-Qiang, Zou Weiping, Piacentini Mauro, Ding Wen-Xing, Yue Zhenyu, Xie Yangchun, Petersen Morten, Gewirtz David A., Mandell Michael A., Chu Charleen T., Sinha Debasish, Eftekharpour Eftekhar, Zhivotovsky Boris, Besteiro Sébastien, Gabrilovich Dmitry I., Kim Do-Hyung, Kagan Valerian E., Bayir Hülya, Chen Guang-Chao, Ayton Scott, Lünemann Jan D., Komatsu Masaaki, Krautwald Stefan, Loos Ben, Baehrecke Eric H., Wang Jiayi, Lane Jon D., Sadoshima Junichi, Yang Wan Seok, Gao Minghui, Münz Christian, Thumm Michael, Kampmann Martin, Yu Di, Lipinski Marta M., Jones Jace W., Jiang Xuejun, Zeh Herbert J., Kang Rui, Klionsky Daniel J., Kroemer Guido, Tang Daolin
Журнал: Autophagy
Том: 20
Номер: 6
Год издания: 2024
Издательство: Landes Bioscience
Местоположение издательства: United States
Первая страница: 1213
Последняя страница: 1246
DOI: 10.1080/15548627.2024.2319901
Аннотация: Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results
Добавил в систему: Животовский Борис Давидович

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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosisстатья