Acute effects of alcohol on unit activity in the motor cortex of freely moving rabbits: comparison with the limbic cortex

ALEXANDROV, Y.I.; GRINCHENKO, Y.V.; LAUKKA, S.; JARVILEHTO, T.; MAZ, V.N.

Авторы: ALEXANDROV Y.I., GRINCHENKO Y.V., LAUKKA S., JARVILEHTO T., MAZ V.N.
Журнал: Acta physiologica Scandinavica
Том: 142
Номер: 3
Год издания: 1991
Издательство: Blackwell Scientific Publications
Местоположение издательства: Oxford, England
Первая страница: 429
Последняя страница: 435
DOI: 10.1111/j.1748-1716.1991.tb09177.x
Аннотация: Unit activity was recorded from the motor cortex of eight freely moving rabbits in order to examine the acute effect of ethanol (1 g kg-1) on organization of unit activity and to compare it with our earlier results from the limbic cortex. The rabbits performed a food-acquisition task in the experimental cage. Unit activity was recorded during behaviour in the control experiment followed by the alcohol experiment on the next day. After ethanol, behavioural mistakes and the duration of the behavioural cycle significantly increased. In the control experiments activation of 58% of the units had no constant relation to the phases of the behavioural cycle (non-involved units), whereas 42% of the units were constantly activated during certain phases (involved units). Two per cent of the latter units were activated in relation to newly learned behavioural acts (e.g. pedal pressing; L units), 28% in relation to food seizure and/or grinding (S units) and 12% in relation to certain movements during different behavioural acts (M units). Ethanol had no effect on the number of active units and the same relation between the number of non-involved and involved units or between the number of different types of involved units was found. However, the number of involved units decreased in the upper and increased in the lower cortical layers. Also the number of units with low background frequency increased, although the frequency within activations did not change. In our earlier study the number of active units in the limbic cortex decreased after ethanol by one third and the relation between the number of L and M units was reversed. Thus, acute effects of ethanol on unit activity in the motor and limbic cortex differ in the number of active units and in their behavioural specialization pattern, both of which change in the limbic, but not in the motor cortex. However, also in the latter the set of involved units changed and manifested as changes in the number of these units in the upper and lower cortical layers. Consequently, the differences between the effects of ethanol on the motor and limbic cortex are not simply quantitative, but ethanol changes the behavioural role of these two cortical areas in qualitatively different ways.
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Acute effects of alcohol on unit activity in the motor cortex of freely moving rabbits: comparison with the limbic cortexстатья

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