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Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cellстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 12 июня 2024 г.
- Авторы: Rzhanova Lyubov A., Markitantova Yuliya V., Aleksandrova Maria A.
- Журнал: Cells
- Том: 13
- Номер: 3
- Год издания: 2024
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 281
- DOI: 10.3390/cells13030281
- Аннотация: : Retinal pigment epithelium (RPE) cells are fundamentally important for the development and function of the retina. In this regard, the study of the morphological and molecular properties of RPE cells, as well as their regenerative capabilities, is of particular importance for biomedicine. However, these studies are complicated by the fact that, despite the external morphological similarity of RPE cells, the RPE is a population of heterogeneous cells, the molecular genetic properties of which have begun to be revealed by sequencing methods only in recent years. This review carries out an analysis of data from morphological and molecular genetic studies of the heterogeneity of RPE cells in mammals and humans, which reveals individual differences in subpopulations of RPE cells and the possible specificity of their functions. Particular attention is paid to discussing the properties of “stemness,” proliferation, and plasticity of the RPE, which may be useful for uncovering the mechanisms of retinal diseases associated with RPE pathologies and finding new ways of treating them.
- Добавил в систему: Александрова Мария Анатольевна