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m6A Methylation in Regulation of Antiviral Innate Immunityстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 мая 2024 г.
- Авторы: Karandashov Ivan, Kachanov Artyom, Dukich Maria, Ponomareva Natalia, Brezgin Sergey, Lukashev Alexander, Pokrovsky Vadim S., Chulanov Vladimir, Kostyusheva Anastasiya, Kostyushev Dmitry
- Журнал: Viruses
- Том: 16
- Номер: 4
- Год издания: 2024
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1
- Последняя страница: 28
- Номер статьи: 601
- DOI: 10.3390/v16040601
- Аннотация: The epitranscriptomic modification m6A is a prevalent RNA modification that plays acrucial role in the regulation of various aspects of RNA metabolism. It has been found to be involvedin a wide range of physiological processes and disease states. Of particular interest is the role of m6Amachinery and modifications in viral infections, serving as an evolutionary marker for distinguishingbetween self and non-self entities. In this review article, we present a comprehensive overview of theepitranscriptomic modification m6A and its implications for the interplay between viruses and theirhost, focusing on immune responses and viral replication. We outline future research directions thathighlight the role of m6A in viral nucleic acid recognition, initiation of antiviral immune responses,and modulation of antiviral signaling pathways. Additionally, we discuss the potential of m6A as aprognostic biomarker and a target for therapeutic interventions in viral infections.
- Добавил в систему: Костюшев Дмитрий Сергеевич