Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver modelстатья

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus, Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 21 июля 2014 г.

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1. PNAS-2014-Khokhlova-8161-6.pdf PNAS-2014-Khokhlova-8161-6.pdf 1,6 МБ 13 августа 2014 [va.khokhlova]
2. Suppl_figures.pdf Suppl_figures.pdf 147,7 КБ 13 августа 2014 [va.khokhlova]

[1] Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model / T. D. Khokhlova, W. Y-N, J. C. Simon et al. // Proceedings of the National Academy of Sciences of the United States of America. — 2014. — Vol. 111, no. 22. — P. 7974–7979. The clinical use of high intensity focused ultrasound (HIFU) therapy for the ablation of benign and malignant tumors and the treatment of a range of neurological disorders has been recently gaining momentum. In HIFU, ultrasound energy from an extracorporeal source is focused within the body to ablate tissue at the focus while leaving the surrounding organs and tissues unaffected. Most HIFU therapies are designed to utilize heating effects resulting from the absorption of ultrasound by tissue to create a thermally coagulated treatment volume. Alternatively, mechanical effects generated by HIFU-induced bubbles can be used to disrupt or, at its extreme, locally fractionate tissue within the focal region. Here we present a novel approach for HIFU-induced ultrasound-guided tissue fractionation, in which a millimeter-sized boiling bubble is generated by ultrasound and further interacts with the ultrasound field to liquefy porcine liver tissue in vivo without inducing further thermal effects. This approach can be very advantageous in a number of clinical applications, in which it is important to accelerate resorption or passage of the ablated tissue volume, diminish pressure on the surrounding organs that causes discomfort, or insert openings between tissues. [ DOI ]

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