Mitocentricity

Zorov, D.B.; Abramicheva, P.A.; Andrianova, N.V.; Babenko, V.A.; Zorova, L.D.; Zorov, S.D.; Pevzner, I.B.; Popkov, V.A.; Semenovich, D.S.; Yakupova, E.I.; Silachev, D.N.; Plotnikov, E.Y.; Sukhikh, G.T.

Авторы: Zorov Dmitry B., Abramicheva Polina A., Andrianova Nadezda V., Babenko Valentina A., Zorova Ljubava D., Zorov Savva D., Pevzner Irina B., Popkov Vasily A., Semenovich Dmitry S., Yakupova Elmira I., Silachev Denis N., Plotnikov Egor Y., Sukhikh Gennady T.
Журнал: Biochemistry (Moscow)
Том: 89
Номер: 2
Год издания: 2024
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 223
Последняя страница: 240
DOI: 10.1134/S0006297924020044
Аннотация: Worldwide, interest in mitochondria is constantly growing, as evidenced by scientific statistics, and studies of the functioning of these organelles are becoming more prevalent than studies of other cellular structures. In this analytical review, mitochondria are conditionally placed in a certain cellular center, which is responsible for both energy production and other non-energetic functions, without which the existence of not only the eukaryotic cell itself, but also the entire organism is impossible. Taking into account the high multifunctionality of mitochondria, such a fundamentally new scheme of cell functioning organization, including mitochondrial management of processes that determine cell survival and death, may be justified. Considering that this issue is dedicated to the memory of V. P. Skulachev, who can be called mitocentric, due to the history of his scientific activity almost entirely aimed at studying mitochondria, this work examines those aspects of mitochondrial functioning that were directly or indirectly the focus of attention of this outstanding scientist. We list all possible known mitochondrial functions, including membrane potential generation, synthesis of Fe-S clusters, steroid hormones, heme, fatty acids, and CO2. Special attention is paid to the participation of mitochondria in the formation and transport of water, as a powerful biochemical cellular and mitochondrial regulator. The history of research on reactive oxygen species that generate mitochondria is subject to significant analysis. In the section “Mitochondria in the center of death”, special emphasis is placed on the analysis of what role and how mitochondria can play and determine the program of death of an organism (phenoptosis) and the contribution made to these studies by V. P. Skulachev.
Добавил в систему: Зоров Дмитрий Бориcович

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Mitocentricityстатья

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