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Synthesis of a tetranitrosyl iron complex with unique structure and properties as an inhibitor of phosphodiesterasesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 января 2024 г.
- Авторы: Sanina N.A., Utenyshev A.N., Dorovatovskii P.V., Emel'yanova N.S., Ovanesyan N.S., Kulikov A.V., Sulimenkov I.V., Luzhkov V.B., Pokidova O.V., Aldoshin S.M.
- Журнал: Dalton Transactions
- Том: 52
- Номер: 47
- Год издания: 2023
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- Первая страница: 18090
- Последняя страница: 18101
- DOI: 10.1039/d3dt03104g
- Аннотация: A novel neutral tetranitrosyl iron complex {[Fe(H2O)4]2+[FeR2(NO)2]22−}·4H2O (1) with R = 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiolyls (C7H5N4S), which is a supramolecular ensemble, has been synthesized and studied. As follows from X-ray diffraction analysis, this is an octahedral Fe2+complex (Lewis acid) with two monoanionic dinitrosyl groups [FeR2(NO)2]− (Lewis base) and 4 water molecules as the ligands. As follows from Mössbauer spectra, the coordinating Fe2+ ion is in a low-spin state S = 0, and the dinitrosyl Fe+ ion is in a low-spin state S = 1/2. According to the data of EPR spectroscopy, mass-spectrometry and amperometry, complex 1 in solution forms dinitrosyl particles of [Fe(C7H6N4S-H)2(NO)2]− composition, which are responsible for NO generation. In addition, complex 1 was shown to be a 5–6 times more efficient phosphodiesterase (PDE) inhibitor at 5 × 10−5 M and 10−4 M concentrations than its thioligand. Probable binding sites of the [FeR2(NO)2]− ligand for the bovine PDE1B model have been determined by molecular docking and quantum-chemical calculations.
- Добавил в систему: Лужков Виктор Борисович