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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Spatial Organization of the Components of the Serotonergic System in the Early Mouse Developmentстатья
- Авторы: Frolova V.S., Ivanova A.D., Konorova M.S., Shmukler Y.B., Nikishin D.A.
- Журнал: Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology
- Том: 17
- Номер: 1
- Год издания: 2023
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 59
- Последняя страница: 64
- DOI: 10.1134/S1990747823060041
- Аннотация: Serotonin is a regulator of early embryonic development and has a complete functional system in preimplantation mammalian embryos. In the present work, the spatial distribution of serotonin, the vesicular monoamine transporter VMAT2, and the 5-HT1D and 5-HT2A receptors at different stages of early embryonic development was described. Serotonin, the VMAT2 transporter, and the 5-HT1D receptor are visualized in the cortical compartment of cells, whereas the 5-HT2A receptor has a more even distribution throughout the cytoplasm. The comparison showed that there were no statistically significant differences between the immunoreactive particle sizes of serotonin and the VMAT2 transporter, suggesting the presence of vesicles in which serotonin accumulates with the involvement of VMAT2 for further intercellular signal transduction. Moreover, the patterns of immunoreactivity of the two serotonin receptors, 5-HT1D and 5-HT2A, differ markedly, which may indicate that they simultaneously serve different functions in early embryogenesis.
- Добавил в систему: Фролова Вероника Сергеевна