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Modulation of neural activity in the external globus pallidus nucleus alters excessive oscillations in the basal ganglia-cortical motor circuits and modifies motor function in hemiparkinsonian ratsтезисы доклада
- Авторы: NOVIKOV N., BRAZHNIK E., MYSIN I., SHUBINA L., POPOVA L.
- Сборник: Program No. PRST154.17/EE2. 2023 Neuroscience Meeting Planner; Society for Neuroscience, 2023
- Тезисы
- Год издания: 2023
- Место издания: Online Washington, D.C
- Первая страница: 667
- Последняя страница: 668
- Номер статьи: PSTR154.17
- Аннотация: Excessive synchronization of local field potential activity (LFP) in the 30-Hz range in the basal ganglia (BG) of Parkinson's disease (PD) patients, and in rodent models of PD is thought to contribute to motor dysfunction in PD. The mechanisms underlying the abnormal LFP patterns are not fully understood. Although exaggerated oscillations have been observed in several BG nuclei in PD, it is still unclear whether it manifests in the external globus pallidus (GPe), as the key nucleus of the BG network. The aim of this study was to determine the role of GPe in generating and transmitting of excessive oscillations through motor neural circuits in ratmodel of PD. The GPe receives inputs from the major BG nuclei, dorsal striatum (dSTR) andsubthalamic nucleus (STN) and provides back inhibitory outputs to STN, dSTR, and substantianigra pars reticulata (SNr). This study uses the behaving rats with 6-OHDA-induced unilateraldopamine cell lesion to gain insight into the potential role of the GPe in supporting expression of LFP oscillations in the motor circuits. Electrodes were implanted in the BG nuclei, motor (MCx) and prefrontal (PFC) cortex. Cannula was inserted into the GPe in a separate group of rats to allow modulation of GPe activity via local infusion of muscimol, a GABA-A agonist,picrotoxin,a GABA-A antagonist, or glutamate receptors antagonists (GluR-ant). It was suggested thatactivity in the GPe contributes to the expression of exaggerated beta oscillations in the BG andmay play a role in supporting PD motor symptoms. Our recent observations have shown that unlike the MCx, SNr and STN, beta oscillations are not very much evident in recordings from the GPe and dStr in PD rats, showing low coherence with recordings from MCx. Apart from beta oscillations, marked increase of coherent 50-56 Hz gamma oscillations was observed exclusively in the dStr, GPe and PFC. Also, we explored the effects of reversal modulation of neuronal activity in the GPe with local infusion of muscimol, picrotoxin, or GluR-ant on the severity of aberrant oscillations and the ability to restore locomotion in rats with PD. Noticeably, all treatments, causing inhibition or activation of neural activity in GPe, lead to strong reduction in power of beta and gamma oscillations and restoration of locomotion. In rats treated with high doses of levodopa, triggering levodopa-induced dyskinesia (LID), the infusion of muscimol to GPe abolished 100-Hz gamma oscillations in BG-cortical circuits and significantly reduced the incidence of LID. The results revealed the ultimate role of GPe, as a critical component of the BG, in controlling motor circuits activity and motor function in PD.
- Добавил в систему: Попова Людмила Борисовна