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Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitorsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Kulikova Larisa N., Raesi Ghulam Reza, Levickaya Daria D., Purgatorio Rosa, Spada Gabriella La, Catto Marco, Altomare Cosimo D., Voskressensky Leonid G.
- Журнал: Molecules
- Том: 28
- Номер: 4
- Год издания: 2023
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1662
- Последняя страница: 1662
- DOI: 10.3390/molecules28041662
- Аннотация: In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including 1-phenylethynyl (5), 1-indol-3-yl (8), and azocino[4,5-b]quinoline (10) derivatives, were synthesized and characterized herein for the first time. Among the newly synthesized derivatives, 5c\u2013h proved to be MAO B inhibitors with potency in the low micromolar range. In particular, the 1-(2-(4-fluorophenyl)ethynyl) analog 5g achieved an IC50 of 1.35 \u03bcM, a value close to that of the well-known MAO B inhibitor pargyline.
- Добавил в систему: Малошицкая Ольга Александровна