|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Crystalline Micro-Sized Carbonated Apatites: Chemical Anisotropy of the Crystallite Surfaces, Biocompatibility, Osteoconductivity, and Osteoinductive Effect Enhanced by Poly(ethylene phosphoric acid)статья
- Авторы: Nifant’ev Ilya E., Tavtorkin Alexander N., Ryndyk Maria P., Gavrilov Dmitry E., Lukina Yulia S., Bionyshev-Abramov Leonid L., Serejnikova Natalya B., Smolentsev Dmitriiy V., Ivchenko Pavel V.
- Журнал: ACS Applied Bio Materials
- Год издания: 2023
- Издательство: American Chemical Society
- Местоположение издательства: United States
- DOI: 10.1021/acsabm.3c00753
- Аннотация: Carbonated hydroxyapatites (CAp) is very close to natural bone apatite in chemical composition and is regarded as a prospective bone mineral substitute for bone surgery and orthopedics. However, until now, the studies and applications of CAp were limited by amorphous nature of the synthetic CAp. In the present work, micro-sized highly crystalline carbonated apatites with uniform hexagonal (hCAp) or plate-like (pCAp) morphology have been studied for the first time in vitro and in vivo, comparing against commercial hydroxyapatite (HAp) and β-tricalcuim phosphate (βTCP). In vitro experiments on dissolution of those calcium phosphate ceramics (CPCs) in acetate (pH 5.5) and Tris (pH 7.3) buffer solutions showed the following rank order of the dissolution rates: βTCP > hCAp > pCAp > HAp. The higher dissolution rate of hCAp in comparison with pCAp is explained by chemical anisotropy of the crystallite surfaces, which was proven by SEM studies of the changes in the morphology of hCAp and pCAp crystallites during hydrolysis. A five-week experiment on subcutaneous implantation of CPC species showed the following rank order of bioresorption rates: βTCP > pCAp > hCAp > HAp. pCAp matrixes exhibited the highest biocompatibility, confirmed by histomorphological analysis. Three-month bone regeneration experiments involving a rat tibial defect model were conducted with 250–500 μm granules of pCAp and pCAp-PEPA (pCAp, pre-treated with 2 wt% poly(ethylene phosphoric acid)). Notably, pCAp-PEPA implants were resorbed at higher rates and induced the formation of more mature osseous tissue, a compact bone with Haversian systems.
- Добавил в систему: Нифантьев Илья Эдуардович