Analyzing features of measles immune response in adult patientsстатья
Статья опубликована в журнале из списка RSCI Web of Science
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
Аннотация:Measles is a highly contagious, vaccine–preventable anthroponotic infection. Despite the policy of active vaccination against this infection of the whole world population, measles has not completely disappeared, it then fades, then outbreaks reappear. It has been shown that not only the unvaccinated are involved in the measles disease, which is quite understandable, but also the vaccinated. Purpose of the work: to study the features of the immune response in adult patients with measles in the conditions of an increase in the incidence in the process of eliminating this infection. 1158 blood sera from measles patients aged 18 to 70 living in Moscow and the Moscow region were studied by ELISA (Euroimmun, Germany). The vast majority of cases are aged 18-40 years - 72.36%. 69 sera taken at a later date (10-20 days from rash) were excluded and considered separately. According to the level of anti-measles IgG and their avidity, the following were distinguished: group 1 with a primary type of immune response 582 sera (53.44%) - these people were not vaccinated in childhood; group 2 (secondary response) 446 sera (40.96%) - these people were vaccinated in childhood, but lost anti-measles antibodies; 61 sera with an intermediate level of parameters were assigned to group 3. To clarify the type of immune response in group 3, an additional analysis of the spectrum of subclasses of anti-measles antibodies was carried out. It was shown that in this group a mixed type of response was detected: 31 people responded with an advantage of the primary type, and 30 people with an advantage of the secondary type of immune response. At the same time, 40 out of 61 people were vaccinated against measles in 1-3 months before the disease, that is, the disease was superimposed on the formation of post-vaccination immunity. Thus, the previously identified trend towards the loss of post-vaccination immunity among older schoolchildren and young adults and the involvement of these people vaccinated in childhood in the epidemic process continues to worsen.