Lel A. Drachev and the Direct Electrometric Methodстатья
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Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
Аннотация:In the bioenergetics studies, the direct electrometric method played an important role. This method is basedon measuring the electrical potential difference (Δψ) between two compartments of the experimental cell generated bysome membrane proteins. These proteins are incorporated into closed lipid–protein membrane vesicles associated withan artificial lipid membrane that separates the compartments. The very existence of such proteins able to generate Δψ wasone of the consequences of Peter Mitchell’s chemiosmotic concept. The discovery and investigation of their functioningcontributed to the recognition of this concept and, eventually the well-deserved awarding of the Nobel Prize to P. Mitchell.Lel A. Drachev (1926-2022) was one of the main authors of the direct electrometrical method. With his participation, keystudies were carried out on the electrogenesis of photosynthetic and respiratory membrane proteins, including bacteriorhodopsin,visual rhodopsin, photosynthetic bacterial reaction centers, cytochrome oxidase and others.