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The role of molecular chaperones in the mechanisms of epileptogenesisстатья
- Авторы: Davletshin AI, Matveeva AA, Poletaeva II, Evgen'ev MB, Garbuz DG
- Журнал: Cell Stress and Chaperones
- Том: 4
- Номер: 9
- Год издания: 2023
- Издательство: Cell Stress Society International
- Местоположение издательства: United States
- DOI: 10.1007/s12192-023-01378-1
- Аннотация: Epilepsy is a group of neurological diseases which requires significant economic costs for the treatment and care of patients.The central point of epileptogenesis stems from the failure of synaptic signal transmission mechanisms, leading to excessivesynchronous excitation of neurons and characteristic epileptic electroencephalogram activity, in typical cases being manifestedas seizures and loss of consciousness. The causes of epilepsy are extremely diverse, which is one of the reasons forthe complexity of selecting a treatment regimen for each individual case and the high frequency of pharmacoresistant cases.Therefore, the search for new drugs and methods of epilepsy treatment requires an advanced study of the molecular mechanismsof epileptogenesis. In this regard, the investigation of molecular chaperones as potential mediators of epileptogenesisseems promising because the chaperones are involved in the processing and regulation of the activity of many key proteinsdirectly responsible for the generation of abnormal neuronal excitation in epilepsy. In this review, we try to systematize currentdata on the role of molecular chaperones in epileptogenesis and discuss the prospects for the use of chemical modulatorsof various chaperone groups’ activity as promising antiepileptic drugs.
- Добавил в систему: Полетаева Инга Игоревна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | s12192-023-01378-1.pdf | s12192-023-01378-1.pdf | 1,3 МБ | 22 ноября 2023 [IPoletaeva] |