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The Role of Brain Monoamines in the Formation of Audiogenic Myoclonic Seizures in Krushinsky–Molodkina Ratsстатья
Дата последнего поиска статьи во внешних источниках: 24 июля 2024 г.
- Авторы: Litvinova S.A., Voronina T.A., Kudrin V.S., Narkevich V.B., Surina N.M., Poletaeva I.I., Fedotova I.B.
- Журнал: Neurochemical Journal
- Том: 17
- Номер: 1
- Год издания: 2023
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 84
- Последняя страница: 90
- DOI: 10.1134/S1819712423010130
- Аннотация: Experiments were carried out on rats of the Krushinsky–Molodkina (KM) strain without soundstimulation (KM-baseline group) and after the development of audiogenic kindling (AuK) in them (KM-AuKgroup). The control group was rats of the “0” strain, in which convulsions in response to sound were completely absent. AuK was generated using 20 repeated sound stimulation (120 dB). Neurochemical analysis wasperformed by HPLC/ED in the frontal cortex, hippocampus, hypothalamus, striatum, nucleus accumbens,and brainstem. It was shown that in KM rats AuK leads to the appearance of myoclonic seizures and adecrease in the intensity of generalized convulsive seizures, which is accompanied by a change in the functional activity of the noradrenergic and serotonergic systems of the brain. KM rats in the baseline (withoutthe action of sound and the development of seizures) show a low content of norepinephrine in the hippocampus and hypothalamus, and during the development of AuK, noradrenaline deficiency is observed in thefrontal cortex. After the formation of AuK, the serotonin metabolism, which is more intense than in the “0”rats, slows in the hippocampus, nucleus accumbens, and, especially, in the brainstem, and the serotonin deficiency in the striatum disappears. The features of noradrenaline metabolism in KM rats before and after AuKemphasize the important role of the cortex in the development of myoclonic seizures, as well as the possibleinvolvement of the hippocampus and hypothalamus in tonic–clonic seizures. The high functional activity ofthe serotonergic system, which was revealed in KM rats in a number of brain structures, weakens in the baseline during the development of AuK. The results we obtained demonstrate and confirm the significant roleof a brain monoamine imbalance in the genesis of epileptiform seizures in KM rats with genetically determined audiogenic epilepsy and in the development of AuK in them.
- Добавил в систему: Сурина Наталья Михайловна
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