The role of sperm-specific glyceraldehyde-3-phosphate dehydrogenase in the development of pathologies—from asthenozoospermia to carcinogenesis

Naletova, I.; Schmalhausen, E.; Tomasello, B.; Pozdyshev, D.; Attanasio, F.; Muronetz, V.

Авторы: Naletova Irina, Schmalhausen Elena, Tomasello Barbara, Pozdyshev Denis, Attanasio Francesco, Muronetz Vladimir
Журнал: Frontiers in Molecular Biosciences
Том: 10
Год издания: 2023
Издательство: Frontiers Media S.A.
Местоположение издательства: Lausanne, Switzerland
DOI: 10.3389/fmolb.2023.1256963
Аннотация: The review considers various aspects of the influence of the glycolytic enzyme,sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDS) on theenergy metabolism of spermatozoa and on the occurrence of severalpathologies both in spermatozoa and in other cells. GAPDS is a uniqueenzyme normally found only in mammalian spermatozoa. GAPDS providesmovement of the sperm flagellum through the ATP formation in glycolyticreactions. Oxidation of cysteine residues in GAPDS results in inactivation of theenzyme and decreases sperm motility. In particular, reduced sperm motility indiabetes can be associated with GAPDS oxidation by superoxide anion producedduring glycation reactions. Mutations in GAPDS gene lead in the loss of motility,and in some cases, disrupts the formation of the structural elements of the spermflagellum, in which the enzyme incorporates during spermiogenesis. GAPDSactivation can be used to increase the spermatozoa fertility, and inhibitors ofthis enzyme are being tried as contraceptives. A truncated GAPDS lacking theN-terminal fragment of 72 amino acids that attaches the enzyme to the spermflagellum was found in melanoma cell lines and then in specimens of melanomaand other tumors. Simultaneous production of the somatic form of GAPDH andsperm-specific GAPDS in cancer cells leads to a reorganization of their energymetabolism, which is accompanied by a change in the efficiency of metastasis ofcertain forms of cancer. Issues related to the use of GAPDS for the diagnosis ofcancer, as well as the possibility of regulating the activity of this enzyme to preventmetastasis, are discussed.
Добавил в систему: Шмальгаузен Елена Викторовна

	ИСТИНА	Войти в систему Регистрация
	Интеллектуальная Система Тематического Исследования НАукометрических данных
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

Интеллектуальная Система Тематического Исследования НАукометрических данных

The role of sperm-specific glyceraldehyde-3-phosphate dehydrogenase in the development of pathologies—from asthenozoospermia to carcinogenesisстатья

Прикрепленные файлы