Investigation of the complex antibiotic INA-5812статья

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Дата последнего поиска статьи во внешних источниках: 20 мая 2017 г.

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[1] Investigation of the complex antibiotic ina-5812 / O. A. Lapchinskaya, G. S. Katrukha, E. G. Gladkikh et al. // Russian Journal of Bioorganic Chemistry. — 2016. — Vol. 42, no. 6. — P. 664–671. A concentrate with the antimicrobial activity has been isolated from the culture broth of Streptomyces roseoflavus INA-Ac-5812. Its further fractionation by reversed-phase HPLC has resulted in six fractions. It has been established by MALDI-TOF and ESI-MSn precision mass-spectrometry methods that the main components of the complex antibiotic are several closely related compounds, presumably of a glycopeptide nature. The fraction containing an individual component with a mass of 1845.788 Da has been characterized by UV/Vis absorbance and fluorescence spectra, amino acid analysis, and derivatization with tris(2,6-dimethoxyphenyl)methyl cation. The activity of fractions against pathogenic microbes has been studied. The results allow the supposition that the INA-5812 antibiotic complex is a glyco- or lipoglycopeptide antibiotic of a new type, which is very promising for further study. [ DOI ]

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