Use of a recombinant human follicle-stimulating hormone:recombinant human luteinizing hormone (r-hFSH:r-hLH) 2:1 combination for controlled ovarian stimulation during assisted reproductive technology treatment: A real-world study of routine practice in th

Koloda, Y.; Korsak, V.; Rozenson, O.; Anshina, M.; Sagamonova, K.; Baranov, I.; Yakovenko, S.; D'Hooghe, T.; Ershova, A.; Lispi, M.

Авторы: Koloda Yulia, Korsak Vladislav, Rozenson Oleg, Anshina Margarita, Sagamonova Karina, Baranov Igor, Yakovenko Sergey, D'Hooghe Thomas, Ershova Anna, Lispi Monica
Журнал: Best Practice and Research in Clinical Obstetrics and Gynaecology
Том: 85
Номер: Part B
Год издания: 2022
Издательство: Bailliere Tindall And Cassell
Местоположение издательства: United Kingdom
Первая страница: 134
Последняя страница: 148
DOI: 10.1016/j.bpobgyn.2022.01.009
Аннотация: Abstract: Two observational studies in the Russian Federation described patient demographics/clinical decision for treatment with recombinant human follicle-stimulating hormone:recombinant human luteinizing hormone (r-hFSH:r-hLH) 2:1 combination for ovarian stimulation (OS) during assisted reproductive technology (ART) and outcomes, respectively. The first (prospective) study enrolled 500 patients. After post-hoc regrouping to assign patients to discrete groups, 378 (75.6%) met the local Russian label for an r-hFSH:r-hLH 2:1 combination, 105 (21%) were treated according to other physician preference, and 17 (3.4%) met only the ESHRE Bologna criteria for a poor ovarian response. The clinical pregnancy rate per cycle was 30.4%. A total of 158/175 (90.3%) women achieving clinical pregnancy in the prospective study participated in the second (retrospective) study. The live birth rate per cycle was 25.8%. No new safety concerns were reported. These results support the use of the r-hFSH:r-hLH 2:1 combination in patients with a poor/suboptimal response to OS for ART treatment in the Russian Federation.
Добавил в систему: Яковенко Сергей Александрович

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