Interferon gamma-dependent transactivation of epidermal growth factor receptorстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 мая 2017 г.
Аннотация:The present report provides evidence that, in A431 cells, interferon
g (IFNg) induces the rapid (within 5 min), and reversible, tyrosine
phosphorylation of the epidermal growth factor receptor (EGFR). IFNg-induced
EGFR transactivation requires EGFR kinase activity, as well as activity of the
Src-family tyrosine kinases and JAK2. Here, we show that IFNg-induced STAT1
activation in A431 and HeLa cells partially depends on the kinase activity of
both EGFR and Src. Furthermore, in these cells, EGFR kinase activity is
essential for IFNg-induced ERK1,2 activation. This study is the first to
demonstrate that EGFR is implicated in IFNg-dependent signaling pathways.