Conformation-dependent sequence design of copolymers - Example of bio-evolution mimetics approachстатья

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Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.

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[1] Conformation-dependent sequence design of copolymers - example of bio-evolution mimetics approach / A. R. Khokhlov, V. A. Ivanov, A. V. Chertovich et al. // STRUCTURE AND DYNAMICS OF CONFINED POLYMERS. — Vol. 87 of NATO SCIENCE SERIES, PARTNERSHIP SUB-SERIES 3. — SPRINGER PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS, 2002. — P. 333–350. We present recent data from our Monte Carlo computer simulation study of the properties of AB-copolymer globules that depend strongly on the primary sequence of the A and B monomers. Several primary sequences were studied: random, random-block, regular, and designed sequences. By using the spatial conformation of the homopolymer chain we compared three models: protein-like copolymers, AB-copolymers modeling membrane proteins, and ABC-copolymers modeling proteins with an active enzymatic center. We found evidence that an AB-copolymer chain with a primary sequence prepared on the basis of a particular conformation of a homopolymer chain by a coloring procedure preserves memory about its parent spatial conformation. By analyzing the power spectra of AB-sequences, we find long-range power-law correlations for the copolymers with the designed primary sequences.

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