Evolution of Restriction–Modification Systems Consisting of One Restriction Endonuclease and Two DNA Methyltransferases

Fokina, A.S.; Karyagina, A.S.; Rusinov, I.S.; Moshensky, D.M.; Spirin, S.A.; Alexeevski, A.V.

Авторы: Fokina Anastasiya S., Karyagina Anna S., Rusinov Ivan S., Moshensky Denis M., Spirin Sergey A., Alexeevski Andrey V.
Журнал: Biochemistry (Moscow)
Том: 88
Номер: 2
Год издания: 2023
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 253
Последняя страница: 261
Оригинальные версии: Эволюция систем рестрикции-модификации, содержащих одну эндонуклеазу рестрикции и две ДНК-метилтрансферазы
DOI: 10.1134/s0006297923020086
Аннотация: Some restriction-modification systems contain two DNA methyltransferases. In the present work, we have classified such systems according to the families of catalytic domains present in the restriction endonucleases and both DNA methyltransferases. Evolution of the restriction-modification systems containing an endonuclease with a NOV_C family domain and two DNA methyltransferases, both with DNA_methylase family domains, was investigated in detail. Phylogenetic tree of DNA methyltransferases from the systems of this class consists of two clades of the same size. Two DNA methyltransferases of each restriction-modification system of this class belong to the different clades. This indicates independent evolution of the two methyltransferases. We detected multiple cross-species horizontal transfers of the systems as a whole, as well as the cases of gene transfer between the systems.
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Evolution of Restriction–Modification Systems Consisting of One Restriction Endonuclease and Two DNA Methyltransferasesстатья Перевод