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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Novel stationary phases for HILIC with polymeric functional layers introduced via the Ugi reactionтезисы доклада
- Авторы: Chikurova N., Belyaeva A., Chernobrovkina A., Shpigun O.
- Сборник: HPLC 2023
- Тезисы
- Год издания: 2023
- Аннотация: Using polymers is promising for creating new hydrophilic stationary phases. The formation of apolymeric functional layer can effectively shield the substrate and reduce its influence on theretention of analytes.In this work it is proposed to use the flexible multicomponent Ugi reaction for creating apolymeric functional layer on the substrate surface by “one-pot” synthesis. Novel adsorbentswere obtained by covalent modification of 3-aminopropyl silica substrate with acetaldehyde,2-morpholinoethyl isocyanide, and different polymeric acids such as polylactic, polyacrylic, andpoly(acrylic acid-co-maleic acid). To characterize and compare the synthesized adsorbents, theTanaka test for hydrophilic stationary phases and model mixtures of polar compounds wereused.The influence of the polymer structure on the stationary phase performance was evaluated,namely, the effect of the polymer layer attachment to the silica surface, the number of carboxylgroups in its structure, molecular weight of the polymer, and substrate-to-polymer mass ratio.Increasing the number of carboxyl groups in the functional layer resulted in increasedhydrophilicity and improved separation selectivity for nitrogenous bases and nucleosides andother polar compounds followed by a decrease of anion exchange selectivity. Using polylacticacid in the Ugi reaction led to a decreased hydrophilicity and anion-exchange selectivity of theadsorbent as compared to polyacrylic acid. Different substrate-to-polymer ratios used for thesynthesis allowed to manipulate both hydrophilicity and anion-exchange selectivity. An increasein the molecular weight of the polymeric acid determined an improvement in the separationefficiency for all classes of model analytes.Incorporating different polymeric acids into the functional layer of the adsorbents via the Ugireaction also resulted in reasonable retention and separation of hydrophobic alkylbenzenes inreversed-phase HPLC mode. Thus, the factors influencing chromatographic properties of novelHILIC adsorbents were established, which could help to govern their selectivity and efficiencyand initiate mixed-mode behavior of the stationary phase.
- Добавил в систему: Чикурова Наталья Юрьевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Chikurova_HPLC.pdf | 291,8 КБ | 1 декабря 2023 [Natalia_Chikurova] |