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Does Pallidal Physiology Determine the Success of Unilateral Deep Brain Stimulation in Cervical Dystonia?статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
- Авторы: Sedov A., Gamaleya A., Semenova U., Medvednik R., Tomskiy A., Jinnah HA, Shaikh A.
- Журнал: Advances in Neurobiology
- Том: 31
- Год издания: 2023
- Издательство: SPRINGER PUBLISHING CO
- Местоположение издательства: 11 WEST 42ND STREET, NEW YORK, USA, NY,10036
- Первая страница: 211
- Последняя страница: 221
- DOI: 10.1007/978-3-031-26220-3_12
- Аннотация: Pallidal deep brain stimulation is a well-known surgical treatment for cervical dystonia. The resolution of dystonia typically requires bilateral pallidal stimulation, but in some instances, unilateral stimulation has been successful. In such instances, generally, the stimulated hemisphere was contralateral to the dystonic sternocleidomastoid, but rarely it was ipsilateral. We sought for the physiological features that determine the basis for success and laterality of deep brain stimulation for cervical dystonia with prominent torticollis. We found that pallidal physiology such as high burst to tonic ratio and significant interhemispheric differences in the neuronal firing rate and regularity are critical determinants of successful treatment with unilateral deep brain stimulation. We also found that higher lateralized differences in pallidal physiological parameters predict more robust improvement. In three out of four patients, the stimulation of the hemisphere ipsilateral to the dystonic sternocleidomastoid muscle was effective. These patients did not have any structural brain abnormalities on clinically available imaging studies. One patient responded to the unilateral deep brain stimulation in the hemisphere contralateral to the dystonic sternocleidomastoid. This patient had a structural putamen lesion on brain MRI. These results provide objective parameters determining the success of pallidal deep brain stimulation for treatment of cervical dystonia. The results also depict differences in the pallidal physiology in patients where ipsilateral versus contralateral deep brain stimulation was effective.Keywords: Cervical dystonia; Deep brain stimulation; Globus pallidus; Single-unit activity.
- Добавил в систему: Гамалея Анна Александровна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Basic_and_Translational_Applications_of_the_Network_Theory_… | 10,7 МБ | 25 июня 2023 [agamaleya_nsi] | |
| 2. | Полный текст | alexey-sedov-does-pallidal-physiology-determine-the.pdf | 429,0 КБ | 25 июня 2023 [agamaleya_nsi] |