Continuous Glucose Monitoring in Patients Following Simultaneous Pancreas–Kidney Transplantation: Time in Range and Glucose Variability

Dmitriev, I.V.; Severina, A.S.; Zhuravel, N.S.; Yevloyeva, M.I.; Salimkhanov, R.K.; Shchelykalina, S.P.; Bezunov, E.A.; Shamkhalova, M.S.; Semenova, J.F.; Klimontov, V.V.; Shestakova, M.V.

Авторы: Dmitriev Ilya V., Severina Anastasia S., Zhuravel Nikita S., Yevloyeva Madina I., Salimkhanov Rustam K., Shchelykalina Svetlana P., Bezunov Evgeniy A., Shamkhalova Minara S., Semenova Julia F., Klimontov Vadim V., Shestakova Marina V.
Журнал: DIAGNOSTICS
Том: 13
Номер: 9
Год издания: 2023
Номер статьи: 1606
DOI: 10.3390/diagnostics13091606
Аннотация: Simultaneous pancreas–kidney transplantation (SPKT) can improve long-term patient survival and restore endogenous insulin secretion in recipients with type 1 diabetes (T1D). There are currently few data on glucose fluctuations assessed by continuous glucose monitoring (CGM) after SPKT. Aim: to evaluate CGM-derived time in range (TIR) and glucose variability (GV) in patients with T1D and functioning pancreatic grafts after SPKT. Fifty-four CGM recordings from 43 patients, 15 men and 28 women, aged 34 (31; 39) years were analyzed. Time since SKPT was up to 1 year (group 1, n = 13), from 1 to 5 years (group 2, n = 15), and from 5 to 12 years (group 3, n = 26). TIR (3.9–10 mmol/L), Time Above Range (TAR), Time Below Range (TBR), and GV parameters were estimated. There were no differences in mean glucose (5.5 [5.1; 6.2], 5.9 [5.4; 6.2], and 5.9 [5.6; 6.7] mmol/L), TIR (97.6 [92.8–99.1], 97.2 [93.2; 99.1], and 97.5 [93.4; 99]%); TAR (0, 1.8 [1.3; 3.7], and 2.5 [2; 5]%), TBR (5 [3.3; 12.7], 4.1 [2.2; 10.1], and 3.5 [1.3; 6.5]%) and GV parameters between three groups (all p > 0.05). Thus, recipients with functioning pancreatic grafts demonstrate remarkably high TIR and low GV after SPKT.
Добавил в систему: Салимханов Рустам Халилович

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