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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Good neighbors?: Astrocyte connectivity defines repeatable patterns of calcium wavesтезисы доклада
- Авторы: Verveyko Darya V., Verisokin Andrey Y., Postnov Dmitry E., Brazhe Alexey R.
- Сборник: Saratov Fall Meeting 2020: Computations and Data Analysis: from Molecular Processes to Brain Functions
- Тезисы
- Год издания: 2021
- Место издания: SPIE
- DOI: 10.1117/12.2590416
- Аннотация: In theoretical consideration of the collective calcium dynamics in astrocytes, an adequate description of the properties of intercellular connections is as important as the details of intracellular dynamics. We propose and test two alternative approaches to connectivity modeling in a two-dimensional projection spatially detailed model of astrocytic networks. Both approaches are based on the creation of a system of densely packed cells with further detailing the diffusive exchange along the contact lines. The simplest way to organize intercellular communication is to change the degree of connectivity by changing the area of contact of cells without adding special case dynamics at the cell borders. Arguably a more advanced approach is to define a specialized model variant specifically for perimembrane layer at the neighboring cell interfaces. At the same time, we separately describe the dynamics of gap contacts. We compare the simulation results for both approaches and conclude that both methods can be useful at different levels of abstraction.
- Добавил в систему: Браже Алексей Рудольфович