[Influence of acute and chronic administrations of beta-casomorphins on the maternal motivation in albino rats]статья

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Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.

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[1] [influence of acute and chronic administrations of beta-casomorphins on the maternal motivation in albino rats] / V. A. Dubynin, I. u. Ivleva, I. u. Beliaeva et al. // Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. — 2005. — Vol. 91, no. 1. — P. 80–88. The influence of food-derived opioid peptides beta-casomorphines on the manifestation of nursing albino rats maternal behavior was investigated. It was shown that both acute and chronic (during the postnatal period) administration of beta-casomorphin-7 (Tyr-Pro-Phe-Pro-Gly-Pro), the typical representative of this group of peptides, decreases the level of the parental motivation. The effects of beta-casomorphin-7 were naloxone-dependent; N-terminal-reduced analogues had a significantly lesser activity. The obtained results testify in favor of the probable role of casein opioid fragments which were formed in mammary glands of a nursing female, in the development of maternal behavior abnormalities. At the same time, beta-casomorphins could be considered as the limiting factors to the excessive manifestation of the parental motivation.

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