Time-Resolved Optical Spectroscopy as a Versatile Method for Studying the Phototherapeutic Activity of Ruthenium(II) Coordination Compounds

Авторы: Tokarev S.D., Botezatu A.
Журнал: ИНЭОС OPEN
Год издания: 2023
Издательство: Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А. Н. Несмеянова Российской академии наук
Местоположение издательства: Москва
DOI: 10.32931/io2214r
Аннотация: Ruthenium(II) polypyridine complexes of imidazophenanthrolines are widely studied as photosensitizers for photodynamic therapy. The effectiveness of a therapeutic drug is manifested in its high cytotoxicity. Nowadays, the main methods for evaluating the drug effectiveness are still expensive and timeconsuming photobiological studies on cell lines. It would be convenient to have access to simpler but no less reliable methods for evaluating the therapeutic efficacy. This review highlights recent investigations on the correlations between the photophysical behavior of ruthenium(II) complexes and their photobiological efficacy, as well as the possibilities of femto- and nanosecond time-resolved photophysical studies to establish the therapeutic efficacy.
Добавил в систему: Токарев Сергей Дмитриевич

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