CASCADE THREE-COMPONENT SYNTHESIS OF 2-AMINO-4-(FLUOROALKYL)-4,5-DIHYDROPYRANO[3,2-B]INDOLE-3-CARBONITRILES WITH THE INVOLVEMENT OF ALIPHATIC FLUOROCARBONYL COMPOUNDSстатья
Аннотация:A three-component cascade synthesis (3CCS) of 5-acetyl-2-amino-4-(fluoroalkyl)-4,5-dihydropyrano[3,2-b]indole-3-carbonitriles 1a-e based on aliphatic fluorocarbonyl compounds 2a-e with N-acetylindoxyl and malonitrile was carried out. The yields of 3CC synthesis of 1a-e are 51‑76% when carried out at room temperature in the presence of a catalytic amount of organic base. Removal of N-acetyl protection group in 1a-e leads to the formation of indolepyrans 4a-e with high yields of 84-88%. The structure of the compounds was confirmed by 1H, 13C and 19F NMR spectroscopy, mass spectrometry, and elemental analysis data.
