The state of the hemostasis system under conditions of immobilization stress against the background of the experimental metabolic syndrome

Grigorjeva, M.E.; Obergan, T.Y.; Korobovsky, A.V.

Авторы: Grigorjeva M.E., Obergan T.Y., Korobovsky A.V.
Журнал: Biology Bulletin Reviews
Том: 13
Номер: 2
Год издания: 2023
Издательство: Pleiades Pub.
Местоположение издательства: Tortola, British Virgin Islands, British Virgin Islands
Первая страница: 98
Последняя страница: 103
DOI: 10.1134/S2079086423020020
Аннотация: The state of the hemostasis system under conditions of immobilization stress against the background of metabolic syndrome (MS) in male Wistar rats was studied. Two series of experiments were conducted using single and multiple immobilization effects. It was shown that development of MS with maintenance of rats on high-calorie diet led to a decrease in the anticoagulant-fibrinolytic and antiplatelet blood potential. In the plasma of intact rats subjected to both single and multiple immobilization, an increase in blood clotting, platelet aggregation, and a decrease in fibrinolysis were found. The combination of both single and multiple immobilization and MS in rats caused a significant decrease in fibrinolysis, the anticoagulant activity of blood and increased platelet aggregation. A comparative analysis of the indicators of primary and plasma hemostasis under these experimental conditions allows us to conclude that showed that immobilization, regardless of its duration, aggravates the state of hypercoagulation in MS rats. Repeated immobilization stress on the background of metabolic disorders lead to more pronounced hypercoagulation shifts due to an 2-fold increase in platelet aggregation compared with intact animals.
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