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Identification of Cancer-Associated Fibroblasts in Metastatic Lymph Nodes of Colorectal Carcinomaстатья Исследовательская статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 июня 2024 г.
- Авторы: Oleynikova N.A., Kharlova O.A., Malkov P.G., Danilova N.V.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 174
- Номер: 5
- Год издания: 2023
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 634
- Последняя страница: 638
- DOI: 10.1007/s10517-023-05760-y
- Аннотация: Cancer-associated fibroblasts (CAF) are a heterogeneous group of tumor microenvironment cells that are barely studied in metastatic lymph nodes. The presence of CAF in regional metastases of colorectal cancer was assessed by using SMA, PDGFRb, and POD markers; the obtained subpopulations were compared with the primary tumor. A total of 26 cases of colon adenocarcinoma with metastases to regional lymph nodes were studied. Duplex immunohistochemical detection (POD+SMA and PDGFRb+SMA) was carried out by the immunohisto-chemical method. In most cases, POD was absent in metastases (65.4%) and PDGFRb was present (88.5%). The POD and PDGFRb staining in the invasive edge of the tumor did not correlate with metastasis. Attention was drawn to the absence of POD and PDGFRb reactions in a blood vessel embolus, as well as to negative PDGFRb in metastasis in the presence of pronounced PDGFRb in the primary tumor in patients after neoadjuvant therapy.
- Добавил в систему: Мальков Павел Георгиевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 435.pdf | 4,1 МБ | 13 апреля 2023 [malkovp] |