Аннотация:The COVID-19 pandemic being a real challenge for the medical society makes a sharp distinction between the usual practice and the newly implemented solutions and literally rewrites the methodological and bioethical history of modern medicine. The article proposes to analyze this transformation from bioethical and methodological points of view on the example of clinical trials. The article containsa chronological description of clinical trials becoming a part of the evidence-based medicine starting from the ancient times and untilCOVID-19 pandemic, and also includes a description of the main methodological solutions in clinical trials in response to the pandemic in Russia, the USA and EU. It is shown that the proposed modifications of the methodology of clinical trials conduction turned out to be unified in different countries, and the clinical trials area has shown a high flexibility to force majeure cases. The main transformation was the remote way of interaction between participants including the implementation of IT solutions. The COVID-19 pandemic and implemented solutions actualized, however, a number of problematic issues from methodological and bioethical points of view that require further discussions in the scientific community.