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Participation of non-receptor Src-family tyrosine kinases in the formation of neutrophil extracellular trapsстатья
- Автор: Vorobjeva N.V.
- Журнал: Moscow University Biological Sciences Bulletin
- Том: 78
- Номер: 1
- Год издания: 2023
- Издательство: Allerton Press
- Местоположение издательства: New York, N.Y., United States
- Первая страница: 8
- Последняя страница: 13
- Оригинальные версии: Участие митоген-активируемых протеинкиназ р38 и ERK1/2, а также протеинкиназы В Akt1/2 в образовании нейтрофильных внеклеточных ловушек
- Переводные версии: Участие нерецепторных тирозинкиназ Src-семейства в образовании нейтрофильных внеклеточных ловушек
- DOI: 10.3103/S0096392523010078
- Аннотация: Neutrophils release decondensed nuclear chromatin or Neutrophil Extracellular Traps (NETs) inresponse to a great number of physiological and pharmacological stimuli. However, apart from the hostdefensive function, NETs play an essential role in the pathogenesis of various autoimmune, inflammatory,and malignant diseases. Therefore, understanding the molecular mechanisms of NETs formation, usuallyleading to the neutrophil death (NETosis), is important to control the probable aberrant or excessive NETsrelease. The Src-family kinases (Src-kinases) are non-receptor tyrosine kinases that are involved in a variety of human functions. However, their role in NETosis and oxidative burst has not been sufficiently studied. Since three representatives of Src-kinases (Hck, Fgr, and Lyn) have been described in human neutrophils, we studied their contribution to NETosis and oxidative burst using inhibitory analysis. We have shown that Srckinases are involved in the oxidative burst and NETosis induced by the calcium ionophore A23187 but not the mimetic of diacylglycerol phorbol-12-myristate-13-acetate (PMA).
- Добавил в систему: Воробьева Нина Викторовна