Synthesis and clinical examination of novel formulations of ivermection, albendazole and niclosamide for the treatment of equine gastrointestinal helminthosesстатья
Статья опубликована в журнале из списка Web of Science и/или Scopus
Местоположение издательства:Iran, Islamic Republic of
Первая страница:66
Последняя страница:75
Аннотация:AbstractBackground: This study aimed to develop new complex preparations of ivermectin, niclosamide and albendazole based on solid-phase mechanochemical technology, and toevaluate their efficacy against equine nematodosis and cestodosis.Methods: Novel formulation of antiparasitic paste were prepared using joint mechanochemical treatment of ivermectin (0.2 mg/kg bodyweight; BW), niclosamide (10 mg/kgBW) and albendazole (3, 5, 10 mg/kg BW) substances with polyvinylpyrrolidone andarabinogalactan. For the evaluation of activity of different doses of formulations againstgastrointestinal tract helminths a total of 151 adult horses of the Novoaltai breed weighing 450–500 kg naturally infected with strongyles (>150 egg per gram of faeces, EPG),Parascaris spp. (>20 EPG) and Anoplocephala spp. (>10 EPG) were selected. Antiparasiticpastes were orally fed to the horses and faecal egg count reduction counts were comparedprior to and 14 days after the treatment.Results: Pastes with mechanically modified ivermectin showed 91.4–100% efficacyagainst strongyles and Parascaris. Pastes with modified albendazole and niclosamide werealso effective against Anoplocephala in all tested dosages i.e. 78.6–100%. In particular,treatment with two formulations containing i) 0.2 mg ivermectin, 10 mg albendazole, 10mg niclosamide, and ii) 0.2 mg ivermectin, 3 mg albendazole showed 100% efficacyagainst strongyles, Parascaris and Anoplocephala.Conclusion: Solid-phase mechanochemical technology could be applied in equine anthelminthics production. It is suggested that future studies focus on plasma concentration-time profile of these highly effective pastes.
