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Urine S-adenosylmethionine are related to degree of renal insufficiency in patients with chronic kidney diseaseстатья
- Авторы: Kruglova M.P., Ivanov A.V., Virus E.D., Bulgakova P.O., Samokhin A.S., Fedoseev A.N., Grachev S.V., Kubatiev A.A.
- Журнал: Laboratory Medicine
- Том: 52
- Номер: 1
- Год издания: 2020
- Издательство: American Society for Clinical Pathology
- Местоположение издательства: United States
- Первая страница: 47
- Последняя страница: 56
- DOI: 10.1093/labmed/lmaa034
- Аннотация: Objective: To determine whether urine S-adenosylmethionine (SAM) might be an indicator of chronic kidney disease (CKD).Methods: We investigated urine levels of SAM and related metabolites (S-adenosylhomocysteine and homocysteine cysteine) in 62 patients (average age, 65.9 years) with CKD (stages II-V).Results: Patients with stages III-V CKD stages have significantly decreased urine levels and SAM/S-adenosylhomocysteine ratio and also cysteine/homocysteine ratio in blood plasma (P <.05), compared with patients with stage II CKD. Urine SAM levels allowed us to distinguish patients with mildly decreased kidney function from those with moderate to severe renal impairment (AUC, 0.791; sensitivity, 85%; specificity, 78.6%).Conclusions: Our study results demonstrate that urine SAM is a potent biomarker for monitoring renal function decline at early CKD stages. Urine SAM testing confers an additional advantage to healthcare professionals in that it is noninvasive.
- Добавил в систему: Ставрианиди Андрей Николаевич