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Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cellsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 апреля 2017 г.
- Авторы: Sviderskaya E.V., Easty D.J., Lawrence M.A., Sanchez D.P., Negulyaev Y.A., Patel R.H., Anand P., Korchev Y.E., Bennett D.C.
- Журнал: FASEB Journal
- Том: 23
- Номер: 9
- Год издания: 2009
- Издательство: Federation of American Societies for Experimental Biology
- Местоположение издательства: United States
- Первая страница: 3179
- Последняя страница: 3192
- DOI: 10.1096/fj.08-123596
- Аннотация: Stem cells, that is, cells that can both reproduce themselves and differentiate into functional cell types, attract much interest as potential aids to healing and disease therapy. Embryonic neural crest is pluripotent and generates the peripheral nervous system, melanocytes, and some connective tissues. Neuralcrest-related stem cells have been reported previously in postnatal skin: committed melanocytic stem cells in the hair follicle, and pluripotent cell types from the hair follicle and papilla that can produce various sets of lineages. Here we describe novel pluripotent neural crest-like stem cells from neonatal mouse epidermis, with different potencies, isolated as 3 independent immortal lines. Using alternative regulatory factors, they could be converted to large numbers of either Schwann precursor cells, pigmented melanocytes, chondrocytes, or functional sensory neurons showing voltage-gated sodium channels. Some of the neurons displayed abundant active TRPV1 and TRPA1 receptors. Such functional neurons have previously been obtained in culture only with difficulty, by explantation. The system was also used to generate comparative gene expression data for the stem cells, melanocytes, and melanoblasts that sufficiently explain the lack of pigment in melanoblasts and provide a rationale for some genes expressed apparently ectopically in melanomas, such as ephrin receptors.-Sviderskaya, E. V., Easty, D. J., Lawrence, M. A., Sanchez, D. P., Negulyaev, Y. A., Patel, R. H., Anand, P., Korchev, Y. E., Bennett, D. C. Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells. FASEB J. 23, 3179-3192 ( 2009). www.fasebj.org
- Добавил в систему: Негуляев Юрий Алексеевич