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Investigations of Electrogenic Ion Transport by Na+,K+-ATPase in Bilayer Lipid Membranes by Impedance Methodстатья
- Автор: Sokolov V.S.
- Журнал: Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology
- Том: 16
- Номер: 4
- Год издания: 2022
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 282
- Последняя страница: 290
- DOI: 10.1134/s1990747822050117
- Аннотация: The results of investigation of electrogenic transport by the Na+,K+-ATPase, the enzyme providing the active transport of Na+ and K+ ions through cell membrane, are reviewed. The main contribution to electric current generated through the functioning of the Na+,K+-ATPase is assigned to the movements of ions in access channels—the channel-like structures connecting the ion binding sites with the solutions. The electrogenic transport was studied in a model system consisting of a bilayer lipid membrane with adsorbed membrane fragments containing the Na+,K+-ATPase. The impedance method applied to this study allowed the investigation of access channels in the Na+,K+-ATPase. The review notes a significant contribution of Yu.A. Chizmadzhev to the development of the theoretical model of transport processes in the Na+,K+-ATPase.
- Добавил в систему: Соколов Валерий Сергеевич