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62P - Identification of tamoxifen-resistant microRNA expression profiles in breast cancer: En route to precision medicine through establishing new biomarkersстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Andreeva O.E., Semina S.E., Scherbakov A.M., Krasil`nikov M.A.
- Журнал: Annals of Oncology
- Том: 30
- Номер: 7
- Год издания: 2019
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- DOI: 10.1093/annonc/mdz413.066
- Аннотация: Breast cancer (BC) is found approximately at 1 million of new cases annually, and mortality reaches 400 thousand. Acquired resistance to tamoxifen limits adjuvant therapy`s potential to combat BC. Notably, up to 50% of ER+ BC cases fail to respond tamoxifen therapy. Elucidating molecular mechanisms of tamoxifen resistance development and transfer is important to develop novel therapies. New biomarkers indicating tamoxifen resistance are also to be found for proper development of precise therapies. Previously we have demonstrated the existence of tamoxifen resistance horizontal transfer at least particularly mediated by exosomes. The latter can carry microRNAs cargo.
- Добавил в систему: Красильников Михаил Александрович