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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Sympathetic System in Wound Healing: Multistage Control in Normal and Diabetic Skinстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Ivanov E.V., Akhmetshina M.R., Erdiakov A.K., Gavrilova S.A.
- Журнал: International Journal of Molecular Sciences
- Том: 24
- Номер: 3
- Год издания: 2023
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 2045
- DOI: 10.3390/ijms24032045
- Аннотация: In this review, we discuss sympathetic regulation in normal and diabetic wound healing. Experimental denervation studies have confirmed that sympathetic nerve endings in skin have an important and complex role in wound healing. Vasoconstrictor neurons secrete norepinephrine (NE) and neuropeptide Y (NPY). Both mediators decrease blood flow and interact with inflammatory cells and keratinocytes. NE acts in an ambiguous way depending on receptor type. Beta2-adrenoceptors could be activated near sympathetic endings; they suppress inflammation and re-epithelialization. Alpha1- and alpha2-adrenoceptors induce inflammation and activate keratinocytes. Sudomotor neurons secrete acetylcholine (ACh) and vasoactive intestinal peptide (VIP). Both induce vasodilatation, angiogenesis, inflammation, keratinocytes proliferation and migration. In healthy skin, all effects are important for successful healing. In treatment of diabetic ulcers, mediator balance could be shifted in different ways. Beta2-adrenoceptors blockade and nicotinic ACh receptors activation are the most promising directions in treatment of diabetic ulcers with neuropathy, but they require further research.Keywords: diabetes mellitus; wound healing; sympathetic system; norepinephrine; acetylcholine; NPY; VIP; NGF; keratinocytes; angiogenesis
- Добавил в систему: Ердяков Алексей Константинович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | ijms-24-02045.pdf | 1016,5 КБ | 25 августа 2023 [Lisitsyna89] |